Abstract Polycomb repressive complex 1 (PRC1) plays essential roles in cell fate decisions
and development. However, its role in cancer is less well understood. Here, we show that …

The Epstein–Barr nuclear antigen 3 (EBNA3) family of proteins, comprising EBNA3A,
EBNA3B, and EBNA3C, play pivotal roles in the asymptomatic persistence and life-long …

The genomic loci associated with B cell differentiation that are subject to transcriptional and
epigenetic regulation in vivo are not well defined, leaving a gap in our understanding of the …

Epigenetic remodeling is required during B cell differentiation. However, little is known about
the direct functions of epigenetic enzymes in Ab-secreting cells (ASC) in vivo. In this study …

Polycomb group (PcG) proteins maintain the silenced state of key developmental genes in
animals, but how these proteins are recruited to specific regions of the genome is still poorly …

In adult tissues and organs with high turnover rates, the generation of transit-amplifying cell
(TAC) populations from self-renewing stem cells drives cell replacement. The role of stem …

Transcriptional co-activator Prdm16 controls brown fat development and white fat browning,
but how this thermogenic function is modulated post-translationally is poorly understood …

Recent studies on Polycomb repressive complexes (PRC) reveal a surprising role in
transcriptional activation, yet the underlying mechanism remains poorly understood. We …

Aurora kinase B (AurkB) is a serine/threonine protein kinase with a well-characterised role in
orchestrating cell division and cytokinesis, and is prominently expressed in healthy …

Polycomb silencing is an important and rapidly growing field that is relevant to a broad
range of aspects of human health, including cancer and stem cell biology. To date, the …