Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

Cancer is a disease of multicellularity; it originates when cells become dysregulated due to
mutations and grow out of control, invading other tissues and provoking discomfort …

Abstract Gene3D (http://gene3d. biochem. ucl. ac. uk) is a database of globular domain
annotations for millions of available protein sequences. Gene3D has previously featured in …

Large-bodied organisms have more cells that can potentially turn cancerous than small-
bodied organisms, imposing an increased risk of developing cancer. This expectation …

Mammalian species differ dramatically in telomere biology. Species larger than 5–10 kg
repress somatic telomerase activity and have shorter telomeres, leading to replicative …

Despite the importance of duplicate genes for evolutionary adaptation, accurate gene
annotation is often incomplete, incorrect, or lacking in regions of segmental duplication. We …

The identity of most functional elements in the mammalian genome and the phenotypes they
impact are unclear. Here, we perform a genome-wide comparative analysis of patterns of …

Popular understanding holds that genetic changes create cancer. James DeGregori uses
evolutionary principles to propose a new way of thinking about cancerÕs occurrence …

Waddington's epigenetic landscape was introduced in biology for understanding the
complex process of metazoan development in an accessible fashion. The epigenetic …

TP53 is the most frequently mutated gene in cancer and its study helped to define
fundamental principles underlying tumorigenesis. However, despite over three decades of …