Therapeutic targeting of mTOR in T-cell acute lymphoblastic leukemia: an update
C Evangelisti, F Chiarini, JA McCubrey… - International journal of …, 2018 - mdpi.com
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood malignancy that arises
from the clonal expansion of transformed T-cell precursors. Although T-ALL prognosis has …
from the clonal expansion of transformed T-cell precursors. Although T-ALL prognosis has …
Notch in leukemia
AC McCarter, Q Wang, M Chiang - Molecular mechanisms of notch …, 2018 - Springer
Notch is commonly activated in lymphoid malignancies through ligand-independent and
ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) …
ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) …
Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load
HD Li, I Cuevas, M Zhang, C Lu… - The Journal of …, 2018 - Am Soc Clin Investig
Mutations underlie all cancers, and their identification and study are the foundation of cancer
biology. We describe what we believe to be a novel approach to mutagenesis and cancer …
biology. We describe what we believe to be a novel approach to mutagenesis and cancer …
Biological aspects of mTOR in leukemia
S Mirabilii, MR Ricciardi, M Piedimonte… - International journal of …, 2018 - mdpi.com
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular
signals, regulating many fundamental cellular processes such as metabolism, growth …
signals, regulating many fundamental cellular processes such as metabolism, growth …
Long non-coding RNA PVT1 as a novel candidate for targeted therapy in hematologic malignancies
Cancerous cells show resistance to various forms of therapy, so applying up to the minute
targeted therapy is crucial. For this purpose, long non-coding RNA PVT1 as shown by recent …
targeted therapy is crucial. For this purpose, long non-coding RNA PVT1 as shown by recent …
Differential co-expression and regulatory network analysis uncover the relapse factor and mechanism of T cell acute leukemia
The pediatric T cell acute lymphoblastic leukemia (T-ALL) still remains a cancer with worst
prognosis for high recurrence. Massive studies were conducted for the leukemia relapse …
prognosis for high recurrence. Massive studies were conducted for the leukemia relapse …
[HTML][HTML] MicroRNA-26b suppresses tumorigenicity and promotes apoptosis in small cell lung cancer cells by targeting myeloid cell leukemia 1 protein
JG Yu, CH Ji, MH Shi - The Kaohsiung Journal of Medical Sciences, 2018 - Elsevier
The aim of this study was to investigate the role of microRNA-26b (miR-26b) in regulating
the proliferation, migration, and apoptosis of small cell lung cancer (SCLC) cells. First, we …
the proliferation, migration, and apoptosis of small cell lung cancer (SCLC) cells. First, we …