The disabling degenerative disease osteoarthritis (OA) is prevalent among the global
population. Articular cartilage degeneration is a central feature of OA; therefore, a better …

Hyaluronan (HA) is a natural linear polymer that is one of the main types of extracellular
matrix during the early stage of chondrogenesis. We found that the chondrogenesis of …

Aggrecan is a high molecular weight proteoglycan that plays a critical role in cartilage
structure and the function of joints, providing intervertebral disc and cartilage with the ability …

Nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) are suitable cell candidates
for intervertebral disc (IVD) regeneration. However, little work has been done to determine …

Delta‐like 2 (Dlk2), a glycoprotein highly homologous to Dlk1, belongs to the
Notch/Delta/Serrata family. Dlk2 has been shown to be an important regulator of …

Osteoarthritis results from a chronic inflammation-mediated destruction of synovial joints
particularly in the hand, hip, and knee. Intervention strategies primarily focus on reducing …

Abstract Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid metabolizing enzyme
present in the endoplasmic reticulum and plasma membranes of cells has important roles in …

Articular cartilage is an extraordinary tissue with unique physiological and mechanical
characteristics. However, when damaged, articular cartilage has a very limited capacity to …

Abstract Lineage-specific Cre Tg mice are widely used to delineate the functions of genes in
a tissue-specific manner. Several T cell-specific promoter cassettes have been developed …