Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance
JA Katzenellenbogen, CG Mayne… - Nature Reviews …, 2018 - nature.com
Oestrogen receptor-α (ERα), a key driver of breast cancer, normally requires oestrogen for
activation. Mutations that constitutively activate ERα without the need for hormone binding …
activation. Mutations that constitutively activate ERα without the need for hormone binding …