Calmodulin (CaM) is a universal regulator for a huge number of proteins in all eukaryotic
cells. Best known is its function as a calcium-dependent modulator of the activity of enzymes …

Background Epidemiological and clinical studies have largely demonstrated major
differences in the prevalence of metabolic disorders in males and females, but the biological …

In this study, for the first time we discovered that the M1/M2 macrophage phenotype ratio is
increased in bone marrow of ovariectomized (OVX) osteoporotic C57BL/6 mice. Considering …

In this study, the electronic properties of bioactive proteins were analyzed using an ab initio
fragment molecular orbital (FMO) methodology in solution: coupling with an implicit solvent …

Airway smooth muscle (ASM) cell hyperplasia driven by persistent inflammation is a
hallmark feature of remodeling in asthma. Sex steroid signaling in the lungs is of …

Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR)
involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a …

Mechanisms of carcinogenesis by estrogen center on its mitogenic and genotoxic potential
on tumor target cells. These models suggest that estrogen receptor (ER) signaling promotes …

As a major phytoestrogen of soy, genistein effectively prevents bone loss in both humans
and rat models of osteoporosis. However, although the bone‐sparing effects of genistein are …

The male factor contributes to 50% of infertility. The cause of male infertility is idiopathic and
could be congenital or acquired. Among different factors which are involved in idiopathic …

The ability to detect breast cancer early in its progression is essential to improve patient
survival and quality of life. The noninvasive and dynamic imaging and functional …