In vivo single cell analysis reveals Gata2 dynamics in cells transitioning to hematopoietic fate

C Eich, J Arlt, CS Vink, P Solaimani Kartalaei… - Journal of Experimental …, 2018 - rupress.org
Cell fate is established through coordinated gene expression programs in individual cells.
Regulatory networks that include the Gata2 transcription factor play central roles in …

Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription

H Wang, J Lapek, K Fujimura, J Strnadel, B Liu… - Cell discovery, 2018 - nature.com
PEAK1 is a newly described tyrosine kinase and scaffold protein that transmits integrin-
mediated extracellular matrix (ECM) signals to facilitate cell movement and growth. While …

Domain‐specific biological functions of the transcription factor Gata2 on hematopoietic differentiation of mouse embryonic stem cells

K Kitajima, M Kanokoda, M Nakajima, T Hara - Genes to Cells, 2018 - Wiley Online Library
The generation of mouse hematopoietic stem cells from hemogenic endothelial cells (HEC
s) in the aorta/gonad/mesonephros region of developing embryos requires a zinc finger …

Clioquinol increases the expression of interleukin-8 by down-regulating GATA-2 and GATA-3

M Katsuyama, M Ibi, K Iwata, M Matsumoto… - Neurotoxicology, 2018 - Elsevier
Clioquinol was used in the mid-1900s as an amebicide to treat indigestion and diarrhea.
However, it was withdrawn from the market in Japan because it was linked to subacute …

[HTML][HTML] PIASy antagonizes Ras-driven NSCLC survival by promoting GATA2 SUMOylation

B Chen, J Luo, Y Zhou, X Xin, R Cai, C Ling - Journal of Cancer, 2018 - ncbi.nlm.nih.gov
GATA2 regulated transcriptional network has been validated requisite for RAS oncogene-
driven non-small cell lung cancer (NSCLC). GATA2 has been reported as a SUMOylated …

Discovery of cardioprotective isoxazole-amide compounds targeting the synergy of transcription factors GATA4 and NKX2-5

M Välimäki - 2018 - oulurepo.oulu.fi
Acute myocardial infarction is a life-threatening condition that occurs as a result of reduced
blood flow in the cardiac muscle, eventually leading to tissue damage. In infarcted areas …

[引用][C] Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2

H Wang, J Lapek, K Fujimura - Cell, 2018