The cell envelope is the first line of defense between a bacterium and the world-at-large.
Often, the initial steps that determine the outcome of chemical warfare, bacteriophage …

Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …

Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming
fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome …

Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ …

Bacteria are confronted with a multitude of stressors when occupying niches within the host.
These stressors originate from host defense mechanisms, other bacteria during niche …

ABSTRACT Lipopolysaccharide (LPS), a cell-associated glycolipid that makes up the outer
leaflet of the outer membrane of Gram-negative bacteria, is a canonical mediator of microbe …

Yersinia pseudotuberculosis replicates within mammalian tissues to form clustered bacterial
replication centers, called microcolonies. A subset of bacterial cells within microcolonies …

The immediate immune response to infection by Gram-negative bacteria depends on the
structure of a lipopolysaccharide (LPS, also known as endotoxin), a complex glycolipid …

In humans and other mammals, recognition of endotoxins—abundant surface
lipopolysaccharides (LPS) of Gram-negative bacteria—provides a potent stimulus for …

Burkholderia pseudomallei causes the severe disease melioidosis. The bacterium subverts
the host immune system and replicates inside cells, and host mortality results primarily from …