The immune system plays a major role in the surveillance and control of malignant cells,
with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers
with very few available treatments. For many decades, gemcitabine was the only treatment …

Interleukin-33 (IL-33), considered as an alarmin released upon tissue stress or damage, is a
member of the IL-1 family and binds the ST2 receptor. First described as a potent initiator of …

Sepsis has always been considered as a big challenge for pharmaceutical companies in
terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves …

Persistent infection by high‑risk human papillomavirus (HR‑HPV) is the main risk factor for
uterine cervical cancer (UCC). However, viral infection alone is not sufficient for the …

OBJECTIVE: The aim of this study was to explore the role of JAK/STAT signaling pathway
inhibitor Ruxolitinib in neutrophilic airway inflammation and its possible immunological …

A resolução de reações inflamatórias é caracterizada pela fagocitose de células mortas,
processo denominado eferocitose. Como consequência deste processo, há a produção dos …

Over the past decades, tumor-resident immune cells have been extensively studied to
dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because …

A resolução de reações inflamatórias é caracterizada pela fagocitose de células mortas,
processo denominado eferocitose. Como consequência deste processo, há a produção dos …

Imatinib representa la terapia de primera línea actual para pacientes con leucemia mieloide
crónica (LMC). Además de su acción directa inhibiendo BCR-ABL1, también podría modular …