Population structure in genetic studies: Confounding factors and mixed models
A genome-wide association study (GWAS) seeks to identify genetic variants that contribute
to the development and progression of a specific disease. Over the past 10 years, new …
to the development and progression of a specific disease. Over the past 10 years, new …
[HTML][HTML] The UK Biobank resource with deep phenotyping and genomic data
C Bycroft, C Freeman, D Petkova, G Band, LT Elliott… - Nature, 2018 - nature.com
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data
collected on approximately 500,000 individuals from across the United Kingdom, aged …
collected on approximately 500,000 individuals from across the United Kingdom, aged …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Meta-analysis of genome-wide association studies for height and body mass index in∼ 700000 individuals of European ancestry
Recent genome-wide association studies (GWAS) of height and body mass index (BMI) in∼
250000 European participants have led to the discovery of∼ 700 and∼ 100 nearly …
250000 European participants have led to the discovery of∼ 700 and∼ 100 nearly …
Embracing polygenicity: a review of methods and tools for psychiatric genetics research
RM Maier, PM Visscher, MR Robinson… - Psychological …, 2018 - cambridge.org
The availability of genome-wide genetic data on hundreds of thousands of people has led to
an equally rapid growth in methodologies available to analyse these data. While the …
an equally rapid growth in methodologies available to analyse these data. While the …
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels …
European-descent individuals (9% cases), after imputation to high-density reference panels …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
E Evangelou, HR Warren, D Mosen-Ansorena… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …
disease. We report the largest genetic association study of blood pressure traits (systolic …
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks,
most binary traits have substantially fewer cases than controls. Both of the widely used …
most binary traits have substantially fewer cases than controls. Both of the widely used …
Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease
P Van Der Harst, N Verweij - Circulation research, 2018 - Am Heart Assoc
Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and
environmental factors. Ninety-seven genetic risk loci have been identified to date, but the …
environmental factors. Ninety-seven genetic risk loci have been identified to date, but the …