Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Diversity and plasticity are the hallmarks of cells from the monocyte–macrophage lineage.
Macrophages undergo classical M1 or alternative M2 activation in response to the …

Wooden Breast Disease (WBD), a myopathy in commercial broiler chickens characterized
by abnormally firm consistency of the pectoral muscle, impacts the poultry industry …

The Tribbles family of pseudokinases recruits substrates to the ubiquitin ligase COP1 to
facilitate ubiquitylation. CCAAT/enhancer-binding protein (C/EBP) family transcription factors …

The elimination of unfit cells from a tissue is a process known in Drosophila and mammals
as cell competition. In a well-studied paradigm “loser” cells that are heterozygous mutant for …

Long non-coding RNAs (lncRNAs) are emerging as important regulators and prognostic
markers of multiple cancers. Our aim was to determine functional involvement of lncRNAs in …

All-trans-retinoic acid (ATRA) and 1α, 25-dihydroxyvitamin D (1, 25D) are potent inducers of
differentiation of myeloid leukemia cells. During myeloid differentiation specific transcription …

Keeping the integrity and transparency of the cornea is the most important issue to ensure
normal vision. There are more than 10 million patients going blind due to the cornea …

Background: Oligonucleotide drug development has revolutionised the drug discovery field.
Within this field,'small'or 'short'activating RNAs (saRNA) are a more recently discovered …