Mechanism of neurotransmitter release coming into focus
J Rizo - Protein Science, 2018 - Wiley Online Library
Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …
Dynamically primed synaptic vesicle states: key to understand synaptic short-term plasticity
E Neher, N Brose - Neuron, 2018 - cell.com
Based on evidence that the docked and primed synaptic vesicle state is very dynamic, we
propose a three-step process for the buildup of the molecular machinery that mediates …
propose a three-step process for the buildup of the molecular machinery that mediates …
Molecular mechanisms of fast neurotransmitter release
AT Brunger, UB Choi, Y Lai, J Leitz… - Annual review of …, 2018 - annualreviews.org
This review summarizes current knowledge of synaptic proteins that are central to synaptic
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …
Vesicle release site organization at synaptic active zones
Abstract Information transfer between nerve cells (neurons) forms the basis of behavior,
emotion, and survival. Signal transduction from one neuron to another occurs at synapses …
emotion, and survival. Signal transduction from one neuron to another occurs at synapses …
Doc2-mediated superpriming supports synaptic augmentation
R Xue, DA Ruhl, JS Briguglio… - Proceedings of the …, 2018 - National Acad Sciences
Various forms of synaptic plasticity underlie aspects of learning and memory. Synaptic
augmentation is a form of short-term plasticity characterized by synaptic enhancement that …
augmentation is a form of short-term plasticity characterized by synaptic enhancement that …
Single bursts of individual granule cells functionally rearrange feedforward inhibition
The sparse single-spike activity of dentate gyrus granule cells (DG GCs) is punctuated by
occasional brief bursts of 3–7 action potentials. It is well-known that such presynaptic bursts …
occasional brief bursts of 3–7 action potentials. It is well-known that such presynaptic bursts …
GPCR regulation of secretion
Modulation of neurotransmitter exocytosis by activated G i/o coupled G-protein coupled
receptors (GPCRs) is a universal regulatory mechanism used both to avoid overstimulation …
receptors (GPCRs) is a universal regulatory mechanism used both to avoid overstimulation …
Vertebrate presynaptic active zone assembly: a role accomplished by diverse molecular and cellular mechanisms
VI Torres, NC Inestrosa - Molecular neurobiology, 2018 - Springer
Among all the biological systems in vertebrates, the central nervous system (CNS) is the
most complex, and its function depends on specialized contacts among neurons called …
most complex, and its function depends on specialized contacts among neurons called …
Apparent calcium dependence of vesicle recruitment
A Ritzau‐Jost, L Jablonski, J Viotti… - The Journal of …, 2018 - Wiley Online Library
Key points Synaptic transmission relies on the recruitment of neurotransmitter‐filled vesicles
to presynaptic release sites. Increased intracellular calcium buffering slows the recovery …
to presynaptic release sites. Increased intracellular calcium buffering slows the recovery …
Bidirectional modulation of glutamatergic synaptic transmission by metabotropic glutamate type 7 receptors at Schaffer collateral–CA1 hippocampal synapses
R Martín, JJ Ferrero, A Collado‐Alsina… - The Journal of …, 2018 - Wiley Online Library
Key points Neurotransmitter release is inhibited by metabotropic glutamate type 7 (mGlu7)
receptors that reduce Ca2+ influx, yet synapses lacking this receptor also produce weaker …
receptors that reduce Ca2+ influx, yet synapses lacking this receptor also produce weaker …