Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Based on evidence that the docked and primed synaptic vesicle state is very dynamic, we
propose a three-step process for the buildup of the molecular machinery that mediates …

This review summarizes current knowledge of synaptic proteins that are central to synaptic
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …

Abstract Information transfer between nerve cells (neurons) forms the basis of behavior,
emotion, and survival. Signal transduction from one neuron to another occurs at synapses …

Various forms of synaptic plasticity underlie aspects of learning and memory. Synaptic
augmentation is a form of short-term plasticity characterized by synaptic enhancement that …

The sparse single-spike activity of dentate gyrus granule cells (DG GCs) is punctuated by
occasional brief bursts of 3–7 action potentials. It is well-known that such presynaptic bursts …

Modulation of neurotransmitter exocytosis by activated G i/o coupled G-protein coupled
receptors (GPCRs) is a universal regulatory mechanism used both to avoid overstimulation …

Among all the biological systems in vertebrates, the central nervous system (CNS) is the
most complex, and its function depends on specialized contacts among neurons called …

Key points Synaptic transmission relies on the recruitment of neurotransmitter‐filled vesicles
to presynaptic release sites. Increased intracellular calcium buffering slows the recovery …

Key points Neurotransmitter release is inhibited by metabotropic glutamate type 7 (mGlu7)
receptors that reduce Ca2+ influx, yet synapses lacking this receptor also produce weaker …