Zinc fingers (ZFs) are among the most structurally diverse protein domains. They interact
with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes …

Proteins actively participate in a wide range of cellular physiological functions. But
aggregation of proteins results in cytotoxicity, and unwanted aggregation of misfolded …

The PI3Kα signaling pathway is frequently hyper-activated in breast cancer (BrCa), as a
result of mutations/amplifications in oncogenes (eg HER2), decreased function in tumor …

Gastric cancer (GC) ranks the third leading cause of global cancer mortality. Despite recent
progress in surgery combined with chemotherapy, the outcomes of GC patients have barely …

Planarians have established a unique body pattern along the anterior‐posterior (AP) axis,
which consists of at least four distinct body regions arranged in an anterior to posterior …

The transcription factor activator protein-1 (AP-1) plays an essential and critical role in the
regulation of numerous downstream genes involved in various physiological and chemical …

E3 ligases and degrons--the sequences they recognize in target proteins--are key parts of
the ubiquitin-mediated proteolysis system. There are several examples of alterations of …

Mitogen activated protein kinase (MAPK) pathway plays a crucial role in maintaining cellular
homeostasis. However, deregulation of its components has been demonstrated to lead to …

The Hect ligases constitute a relatively small superfamily of ubiquitin conjugating enzymes
but are disproportionately represented in a variety of diseases, generating significant …

ERK1 et ERK2 (ERK1/2) sont des kinases membres de la voie de signalisation Ras-MAP
Kinase impliquées dans la régulation de la croissance, de la division ainsi que de la …