[HTML][HTML] Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis
LM Alcântara, TCS Ferreira, FR Gadelha… - International Journal for …, 2018 - Elsevier
Tritryps diseases are devastating parasitic neglected infections caused by Leishmania spp.,
Trypanosoma cruzi and Trypanosoma brucei subspecies. Together, these parasites affect …
Trypanosoma cruzi and Trypanosoma brucei subspecies. Together, these parasites affect …
Correlates of GLA family adjuvants' activities
Lipopolysaccharide (LPS) is a well-defined agonist of Toll-like receptor (TLR) 4 that
activates innate immune responses and influences the development of the adaptive …
activates innate immune responses and influences the development of the adaptive …
Heterologous Immunization With Defined RNA and Subunit Vaccines Enhances T Cell Responses That Protect Against Leishmania donovani
MS Duthie, N Van Hoeven, Z MacMillen… - Frontiers in …, 2018 - frontiersin.org
The rapid generation of strong T cell responses is highly desirable and viral vectors can
have potent CD8+ T cell-inducing activity. Immunity to leishmaniasis requires selective T cell …
have potent CD8+ T cell-inducing activity. Immunity to leishmaniasis requires selective T cell …
Dermotropic Leishmania donovani in Sri Lanka: visceralizing potential in clinical and preclinical studies
The visceralizing potential of apparently dermotropic Leishmania donovani in Sri Lanka (L.
donovani-SL) was investigated through long-term follow-up of cutaneous leishmaniasis (CL) …
donovani-SL) was investigated through long-term follow-up of cutaneous leishmaniasis (CL) …
Phagosome proteomics to study Leishmania's intracellular niche in macrophages
G Semini, T Aebischer - International Journal of Medical Microbiology, 2018 - Elsevier
Intracellular pathogens invade their host cells and replicate within specialized
compartments. In turn, the host cell initiates a defensive response trying to kill the invasive …
compartments. In turn, the host cell initiates a defensive response trying to kill the invasive …
SPATIO-TEMPORAL DISTRIBUTION AND RISK FACTORS ASSOCIATED WITH PHLEBOTOMINE SAND FLIES AND LEISHMANIASIS IN Mt. ELGON REGION …
DW MUKHWANA - 2018 - erepository.uoeld.ac.ke
This study determined the spatio–temporal distribution, natural infection and risk factors
associated with phlebotomine sand flies and leishmaniasis in Mt. Elgon focus in 2015 …
associated with phlebotomine sand flies and leishmaniasis in Mt. Elgon focus in 2015 …
CRISPR/Cas9 Editing of Rhomboid Genes in Leishmania donovani
J Janeaux - 2018 - search.proquest.com
Leishmania donovani is the causative agent of visceral leishmaniasis, a fatal disease that
affects a large portion of the developing world, and has the potential to become a threat to …
affects a large portion of the developing world, and has the potential to become a threat to …