Abstract Noonan syndrome [NS; Mendelian Inheritance in Men (MIM)# 163950] and related
syndromes [Noonan syndrome with multiple lentigines (formerly called LEOPARD …

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …

Cell signaling is the process by which extracellular information is transmitted into the cell to
perform useful biological functions. The ERK (extracellular-signal-regulated kinase) …

Myeloperoxidase (MPO) is a member of the mammalian peroxidase family. It is mainly
expressed in neutrophils, monocytes and macrophages. As a catalyzer of reactive oxidative …

Immune checkpoint blockade therapy targeting CTLA4 and PD-1/PD-L1 is a promising
strategy in the treatment of different types of cancers. However, the clinical success rates of …

It has become clearer that advanced cancer, especially advanced breast cancer, is an
entirely displayed pathological system that is much more complex than previously …

Introduction Noonan syndrome (NS) is an autosomal dominant disorder characterized by
short stature, skeletal and haematological/lymphatic defects, distinctive facies …

Aberrant activation of the Raf‐MEK‐ERK pathway has frequently been associated with
various cancers, especially lung cancer. However, the key regulators of this pathway are …

ABSTRACT EGFR signaling has a critical role in oncogenic KRAS-driven tumorigenesis of
the pancreas, whereas it is dispensable in other organs. The complex signaling network …

Ulinastatin and propofol (PPF) are recognized for their anticancer properties. The aim of the
present study was to evaluate the synergistic antitumor effect of PPF followed by ulinastatin …