Mammalian immune systems evolved within a diverse world dominated by microbes,
making interactions between these two life-forms inevitable. Adaptive immunity protects …

Abstract Background and Aims Population-based prospective cohort studies investigating
fibre intake and development of inflammatory bowel disease are lacking. Our aim was to …

Background Ankylosing spondylitis (AS) results from the combined effects of susceptibility
genes and environmental factors. Polymorphisms in genes regulating inflammation may …

Biological agents including anti-tumor necrosis factor (anti-TNF; adalimumab, infliximab,
etanercept) and anti-interleukin-12/13 (IL12/23; ustekinumab) are essential for treatment of …

Anti-tumour necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory
bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However …

Background Psoriasis (PsO) is a chronic inflammatory disease with predominantly
cutaneous manifestations. Approximately one third of patients with PsO develop psoriatic …

Background Meat and dietary fiber are associated with increased and decreased risk of
colorectal cancer (CRC), respectively. Toll-like receptors (TLRs) regulate the intestinal …

В статье систематизированы литературные данные о роли таргетной терапии в
лечении пациентов с воспалительными заболеваниями кишечника. Представлены …

Toll-like receptor 4 (TLR4) initiates immune response against Gram-negative bacteria upon
specific recognition of lipid A moiety of lipopolysaccharide (LPS), the major component of …

Background Ulcerative colitis (UC) is an idiopathic colonic mucosal disease, and its
pathogenesis has not been fully understood. Up-frameshift protein 1 (UPF1) is a potential …