Cone-rod homeobox (CRX) is a paired-like homeodomain transcription factor (TF) and a
master regulator of photoreceptor development in vertebrates. The in vitro DNA binding …

Double homeobox (DUX) transcription factors are unique to eutherian mammals. DUX4
regulates expression of repetitive elements during early embryogenesis, but misexpression …

Oncogenic fusions are major drivers in leukemogenesis and may serve as potent targets for
treatment. DUX4/IGHs have been shown to trigger the abnormal expression of ERGalt …

Recently, human PAIRED-LIKE homeobox transcription factor (TF) genes were discovered
whose expression is limited to the period of embryo genome activation up to the 8-cell stage …

During mRNA localization, RNA-binding proteins interact with specific structured mRNA
localization motifs. Although several such motifs have been identified, we have limited …

Abstract Characterization and prediction of the DNA-biding regions in proteins are essential
for our understanding of how proteins recognize/bind DNA. We analyze the unbound (U) …

DUX4 plays critical role in the molecular pathogenesis of the neuromuscular disorder
facioscapulohumeral muscular dystrophy and acute lymphoblastic leukemia in humans. As …

The present study investigated the clinical and mutational spectrum of aniridia in a cohort of
17 affected individuals from six families from Cyprus. Each proband was initially evaluated …

Purpose The aim of this study was to detect the genetic defects in a large pedigree of
affected individuals with various phenotypes of ocular anomalies including partial aniridia …

Transcription factors are proteins that bind at promoter and enhancer sites to regulate gene
expression. In this thesis, I used NMR spectroscopy and other methods to investigate the …