Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …

Altered neuronal network formation and function involving dysregulated excitatory and
inhibitory circuits are associated with fragile X syndrome (FXS). We examined functional …

Fragile X syndrome (FXS) is caused by transcriptional silencing of the FMR1 gene during
embryonic development with the consequent loss of the encoded fragile X mental …

There is a strong association between cannabis use and schizophrenia but the underlying
cellular links are poorly understood. Neurons derived from human-induced pluripotent stem …

Fragile X syndrome (FXS) is the most prevalent inherited intellectual disability, resulting from
a loss of fragile X mental retardation protein (FMRP). Patients with FXS suffer lifelong …

The absence of FMR1 protein (FMRP) causes fragile X syndrome (FXS) and disturbed
FMRP function is implicated in several forms of human psychopathology. We show that …

It is widely accepted that human brain development has unique features that cannot be
represented by rodents. Obvious reasons are the evolutionary distance and divergent …

Background Lowe syndrome (LS) is a rare genetic disorder caused by loss of function
mutations in the X-linked gene, OCRL, which codes for inositol polyphosphate 5 …

Autism spectrum disorders (ASD) represent a variety of disorders characterized as complex
lifelong neurodevelopment disabilities, which may affect the ability of communication and …