High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats
F Allain, K Bouayad-Gervais, AN Samaha - Psychopharmacology, 2018 - Springer
Rationale Taking high and increasing amounts of cocaine is thought to be necessary for the
development of addiction. Consequently, a widely used animal model of drug self …
development of addiction. Consequently, a widely used animal model of drug self …
Role of dorsal striatum histone deacetylase 5 in incubation of methamphetamine craving
X Li, MB Carreria, KR Witonsky, T Zeric, OM Lofaro… - Biological …, 2018 - Elsevier
Background Methamphetamine (meth) seeking progressively increases after withdrawal
(incubation of meth craving). We previously demonstrated an association between histone …
(incubation of meth craving). We previously demonstrated an association between histone …
Contributions of prolonged contingent and non-contingent cocaine exposure to escalation of cocaine intake and glutamatergic gene expression
KL Ploense, P Vieira, L Bubalo, G Olivarria, AE Carr… - …, 2018 - Springer
Similar to the pattern observed in people with substance abuse disorders, laboratory
animals will exhibit escalation of cocaine intake when the drug is available over prolonged …
animals will exhibit escalation of cocaine intake when the drug is available over prolonged …
Loren Parsons' contribution to addiction neurobiology
MA De Luca, MW Buczynski, G Di Chiara - Addiction Biology, 2018 - Wiley Online Library
Abstract Loren (Larry) H. Parsons passed away at the age of 51. In spite of his premature
departure, Larry much contributed to the drug abuse field. Since his graduate studies for the …
departure, Larry much contributed to the drug abuse field. Since his graduate studies for the …
Repeated cocaine exposure attenuates the desire to actively avoid: a novel active avoidance runway task
Drug addiction is a disorder in which drug seeking persists despite aversive consequences.
While it is well documented in animal models of drug sensitization that repeated drug …
While it is well documented in animal models of drug sensitization that repeated drug …
Prolonged-access to cocaine induces distinct Homer2 DNA methylation, hydroxymethylation, and transcriptional profiles in the dorsomedial prefrontal cortex of Male …
KL Ploense, X Li, D Baker-Andresen, AE Carr… - …, 2018 - Elsevier
Repeated cocaine administration induces many long-term structural and molecular changes
in the dorsal medial prefrontal cortex (dmPFC) and are known to underlie aspects of cocaine …
in the dorsal medial prefrontal cortex (dmPFC) and are known to underlie aspects of cocaine …
[图书][B] Investigating the Effects of Repeated Cocaine Exposure and Striatal Dopamine D1 and D2 Receptor Antagonism on Reward, Aversion, and Approach …
D Nguyen - 2018 - search.proquest.com
Exposure to psychostimulant drugs induces an enduring state of heightened drug-seeking
motivation, as well as cross-sensitization to natural reinforcers, which has been attributed to …
motivation, as well as cross-sensitization to natural reinforcers, which has been attributed to …
Development and Preclinical Evaluation of Long-lasting Cocaine Hydrolases for Cocaine Overdose and Cocaine Use Disorder Treatment
T Zhang - 2018 - uknowledge.uky.edu
Cocaine is a plant-based illicit drug commonly involved in substance use disorder. Although
cocaine overdose and cocaine use disorders cause adverse health consequences to …
cocaine overdose and cocaine use disorders cause adverse health consequences to …
Characterizing the role of cortical neuronal subtypes and drug intake pattern in cocaine addiction
AF Garcia - 2018 - digital.lib.washington.edu
Drug addiction is a complex neuropsychiatric disorder that takes a great emotional and
financial toll on those who suffer from it as well as society as a whole. Psychologically, drugs …
financial toll on those who suffer from it as well as society as a whole. Psychologically, drugs …