Multimodal HDAC inhibitors with improved anticancer activity
R Schobert, B Biersack - Current Cancer Drug Targets, 2018 - ingentaconnect.com
Histone deacetylases (HDACs) play a significant role in the proliferation and dissemination
of cancer and represent promising epigenetic drug targets. The HDAC inhibitor vorinostat …
of cancer and represent promising epigenetic drug targets. The HDAC inhibitor vorinostat …
Pendant HDAC inhibitor SAHA derivatised polymer as a novel prodrug micellar carrier for anticancer drugs
Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi) approved
by FDA for the treatment of cutaneous T cell lymphoma, is a promising anticancer drug for …
by FDA for the treatment of cutaneous T cell lymphoma, is a promising anticancer drug for …
Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer
T Luu, K Kim, S Blanchard, B Anyang, A Hurria… - Breast Cancer Research …, 2018 - Springer
Purpose To translate promising preclinical data on the combination of vorinostat and
ixabepilone for metastatic breast cancer (MBC) into clinical trials. Methods We conducted a …
ixabepilone for metastatic breast cancer (MBC) into clinical trials. Methods We conducted a …
[HTML][HTML] Targeting HER2 by combination therapies
A Ruiz-Saenz, MM Moasser - … of clinical oncology: official journal of …, 2018 - ncbi.nlm.nih.gov
HER2 was initially recognized 30 years ago as an amplified oncogene in more than 20% of
breast cancers, and following the genomic revolution of the more recent decade, is now …
breast cancers, and following the genomic revolution of the more recent decade, is now …
Uloga žučnih kiselina u epigenetskoj regulaciji oksidativnog stresa i apoptoze u normalnim i malignim ćelijama
N Pavlović - 2018 - search.proquest.com
Žučne kiseline deluju kao signalni molekuli u organizmu i uključene su u regulaciju brojnih
metaboličkih, inflamatornih i imunomodulatornih procesa. Ova endogena jedinjenja …
metaboličkih, inflamatornih i imunomodulatornih procesa. Ova endogena jedinjenja …
[图书][B] Design, Synthesis, and Biological Evaluation of Novel Histone Deacetylase Inhibitors as Anti-Cancer Agents
AAACA Al - 2018 - search.proquest.com
Despite major advances in cancer treatment strategies in recent years, significant limitations
still remain. Selectively targeting cancer cells without affecting normal cells is a challenging …
still remain. Selectively targeting cancer cells without affecting normal cells is a challenging …