Abstract Hypoxia‑ischemia (H‑I) is frequently observed in perinatal asphyxia and other
diseases. It can lead to serious cardiac injury, cerebral damage, neurological disability and …

The development and progression of human cancers are continuously and dynamically
regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic …

High-grade gliomas (HGGs) include the most common and the most aggressive primary
brain tumor of adults and children. Despite multimodality treatment, most high-grade gliomas …

Peripheral nerve injuries are generally associated with incomplete restoration of motor
function. The slow rate of nerve regeneration after injury may account for this. Although …

Hypoxia is common in Glioblastoma (GBM). By regulating the 'hypoxia signaling cascade',
hypoxia affects several processes including cell proliferation, invasion, and angiogenesis …

Advanced glycation end products (AGEs), produced by the non-enzymatic glycation of
proteins and lipids under hyperglycemia or oxidative stress conditions, has been implicated …

SRC family kinase was documented to have vital roles in adjusting cancer cell malignant
behaviors. To date, the role of c-Src, a member of SRC family kinase, in resistance to …

Brain pericytes are important to maintain vascular integrity of the neurovascular unit under
both physiological and ischemic conditions. Ischemic stroke is known to induce an …

Reactions of glutathione (GSH) with O, O-diorganyl dithiophosphoric acids (DTPA) were
studied to develop bioactive derivatives of GSH. Effective coupling reaction of GSH with …

Aim: To investigate the time profile of hypoxia and stem cell markers in glioblastoma
spheroids of known molecular subtype. Materials & methods: Patient-derived glioblastoma …