Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications
MO Goodarzi - The lancet Diabetes & endocrinology, 2018 - thelancet.com
Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
A Hammarstedt, S Gogg, S Hedjazifar… - Physiological …, 2018 - journals.physiology.org
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …
However, it has a limited ability to expand by recruiting and/or differentiating available …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Meta-analysis of genome-wide association studies for height and body mass index in∼ 700000 individuals of European ancestry
Recent genome-wide association studies (GWAS) of height and body mass index (BMI) in∼
250000 European participants have led to the discovery of∼ 700 and∼ 100 nearly …
250000 European participants have led to the discovery of∼ 700 and∼ 100 nearly …
Adverse effects of statin therapy: perception vs. the evidence–focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract
F Mach, KK Ray, O Wiklund, A Corsini… - European heart …, 2018 - academic.oup.com
Aims To objectively appraise evidence for possible adverse effects of long-term statin
therapy on glucose homeostasis, cognitive, renal and hepatic function, and risk for …
therapy on glucose homeostasis, cognitive, renal and hepatic function, and risk for …
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability
Cannabis use is a heritable trait that has been associated with adverse mental health
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Genome-wide association studies (GWAS) have identified> 250 loci for body mass index
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …
Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE
Background/objectives Physical activity (PA) protects against a wide range of diseases.
Habitual PA appears to be heritable, motivating the search for specific genetic variants that …
Habitual PA appears to be heritable, motivating the search for specific genetic variants that …
[HTML][HTML] Sex and gender differences in developmental programming of metabolism
Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …
Determinants of takeaway and fast food consumption: a narrative review
HG Janssen, IG Davies, LD Richardson… - Nutrition research …, 2018 - cambridge.org
Out-of-home foods (takeaway, take-out and fast foods) have become increasingly popular in
recent decades and are thought to be a key driver in increasing levels of overweight and …
recent decades and are thought to be a key driver in increasing levels of overweight and …