Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus
Leishmania, form a group of flagellated protists that threaten human health. These …

As microbial resistance to drugs continues to rise at an alarming rate, finding new ways to
combat pathogens is an issue of utmost importance. Development of novel and specific …

Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to
evade the immune responses of their hosts. These include antigenic variation, through …

Although the genome of Trypanosoma cruzi, the causative agent of Chagas disease, was
first made available in 2005, with additional strains reported later, the intrinsic genome …

African trypanosomes cause lethal and neglected tropical diseases, known as sleeping
sickness in humans and nagana in animals. Current therapies are limited, but fortunately …

ABSTRACT A novel pan-Leishmania loop-mediated isothermal amplification (LAMP) assay
for the diagnosis of cutaneous and visceral leishmaniasis (CL and VL) that can be used in …

The Cas9 endonuclease can be programmed by guide RNA to introduce sequence-specific
breaks in genomic DNA. Thus, Cas9-based approaches present a range of novel options for …

Selective transcription of individual protein coding genes does not occur in trypanosomes
and the cellular copy number of each mRNA must be determined post-transcriptionally …

Trypanosomatids are a group of kinetoplastid parasites including some of great public
health importance, causing debilitating and life-long lasting diseases that affect more than …

Background Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided
into six discrete typing units (DTUs), named TcI-TcVI. TcII is among the major DTUs enrolled …