Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks

EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Switch-like PKA responses in the nucleus of striatal neurons

C Yapo, AG Nair, J Hellgren Kotaleski… - Journal of Cell …, 2018 - journals.biologists.com
Although it is known that protein kinase A (PKA) in the nucleus regulates gene expression,
the specificities of nuclear PKA signaling remain poorly understood. Here, we combined …

LUMINESCENCE-ACTIVATED CYCLASE ALLOWS LOCALIZED PHOTO AND CHEMICAL STIMULATION OF cAMP SYNTHESIS

N Naim - 2018 - d-scholarship.pitt.edu
Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that regulates
cellular proliferation, differentiation, attachment, migration, and several other processes. It …