The transcription factor nuclear factor-κB (NF-κB) modulates gene expression in diverse
cellular processes such as innate immune response, embryogenesis and organ …

Mitochondria are organelles with a highly dynamic ultrastructure maintained by a delicate
equilibrium between its fission and fusion rates. Understanding the factors influencing this …

Background. There are no approved drug treatments for liver fibrosis and nonalcoholic
steatohepatitis (NASH), an advanced stage of fibrosis which has rapidly become a major …

Human innate immunity responds to viral infection by activating the production of interferons
(IFNs) and proinflammatory cytokines. The mitochondrial adaptor molecule MAVS plays a …

In this study, we explored the effects of particulate matter 2.5 (PM 2. 5) eye drops on the
ocular surface structure and tear function in mice and established a novel animal model for …

Multiple myeloma (MM), an incurable plasma cell cancer, represents the second most
prevalent hematological malignancy. Deregulated activity of the nuclear factor kappaB (NF …

During injury and infection, inflammation is a response by macrophages to effect healing
and repair. The kinetics of the responses of proinflammatory TNF α, anti‐inflammatory IL‐10 …

Abstract Background Studies show that Toll-like receptors (TLRs), members of the innate
immune system, might participate in the pathogenesis of the major depressive disorder …

Currently, there are no effective treatments for diabetes-related cognitive dysfunction.
Astaxanthin (AST), the most powerful antioxidant in nature, exhibits diverse biological …

Renal fibrosis is a condition characterized by excessive extracellular matrix accumulation in
the kidney. Representing the final common result of a variety of injuries, it can lead to …