Cancer-associated fibroblasts drive glycolysis in a targetable signaling loop implicated in head and neck squamous cell carcinoma progression
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is
associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists …
associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists …
[HTML][HTML] Metabolic interplay between tumour cells and cancer-associated fibroblasts (CAFs) under hypoxia versus normoxia
The growth of tumour cells is closely related to cancer-associated fibroblasts (CAFs) present
within their microenvironment. CAFs, the most abundant cells in tumour stroma, secrete …
within their microenvironment. CAFs, the most abundant cells in tumour stroma, secrete …
Metabolic signature of squamous cell carcinoma of the head and neck: Consequences of TP53 mutation and therapeutic perspectives
MD Wilkie, AS Lau, N Vlatkovic, TM Jones, MT Boyd - Oral Oncology, 2018 - Elsevier
There is a pressing need to identify ways of sensitising squamous cell carcinomas of the
head and neck (SCCHN) to the effects of current treatments, both from oncological and …
head and neck (SCCHN) to the effects of current treatments, both from oncological and …
MCT4 expression is a potential therapeutic target in colorectal cancer with peritoneal carcinomatosis
HK Kim, IK Lee, H Bang, HC Kim, WY Lee… - Molecular cancer …, 2018 - AACR
Monocarboxylate transporters (MCT) are transmembrane proteins that control the lactate
metabolism and are associated with poor prognosis in solid tumors, including colorectal …
metabolism and are associated with poor prognosis in solid tumors, including colorectal …
[HTML][HTML] Monocarboxylate transporter 4 (MCT4) knockout mice have attenuated 4NQO induced carcinogenesis; a role for MCT4 in driving oral squamous cell cancer
S Bisetto, D Whitaker-Menezes, NA Wilski… - Frontiers in …, 2018 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the 6th most common human cancer
and affects approximately 50,000 new patients every year in the US. The major risk factors …
and affects approximately 50,000 new patients every year in the US. The major risk factors …
[HTML][HTML] Metformin clinical trial in HPV+ and HPV–head and neck squamous cell carcinoma: impact on cancer cell apoptosis and immune infiltrate
Background: Metformin, an oral anti-hyperglycemic drug which inhibits mitochondrial
complex I and oxidative phosphorylation has been reported to correlate with improved …
complex I and oxidative phosphorylation has been reported to correlate with improved …
[HTML][HTML] Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters
M Mehibel, F Ortiz-Martinez, N Voelxen, A Boyers… - Scientific reports, 2018 - nature.com
Prognosis of HPV negative head and neck squamous cell carcinoma (HNSCC) patients
remains poor despite surgical and medical advances and inadequacy of predictive and …
remains poor despite surgical and medical advances and inadequacy of predictive and …
[HTML][HTML] Immunometabolic determinants of chemoradiotherapy response and survival in head and neck squamous cell carcinoma
Tumor immune microenvironment and tumor metabolism are major determinants of
chemoradiotherapy response. The interdependency and prognostic significance of specific …
chemoradiotherapy response. The interdependency and prognostic significance of specific …
[HTML][HTML] Metabolomic alterations in thyrospheres and adherent parental cells in papillary thyroid carcinoma cell lines: a pilot study
P Caria, L Tronci, T Dettori, F Murgia… - International Journal of …, 2018 - mdpi.com
Papillary thyroid carcinoma (PTC), is characterized by a heterogeneous group of cells,
including cancer stem cells (CSCs), crucially involved in tumor initiation, progression and …
including cancer stem cells (CSCs), crucially involved in tumor initiation, progression and …
[HTML][HTML] β2-Adrenergic receptor modulates mitochondrial metabolism and disease progression in recurrent/metastatic HPV(+) HNSCC
The incidence of human papillomavirus-associated head and neck squamous cell
carcinoma (HPV [+] HNSCC) is rapidly increasing. Although clinical management of primary …
carcinoma (HPV [+] HNSCC) is rapidly increasing. Although clinical management of primary …