Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease

EM Rocha, B De Miranda, LH Sanders - Neurobiology of disease, 2018 - Elsevier
Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

N Nissanka, CT Moraes - FEBS letters, 2018 - Wiley Online Library
Mitochondria are essential organelles within the cell where most ATP is produced through
oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are …

Anti–tumor necrosis factor therapy and incidence of Parkinson disease among patients with inflammatory bowel disease

I Peter, M Dubinsky, S Bressman, A Park, C Lu… - JAMA …, 2018 - jamanetwork.com
Importance Despite established genetic and pathophysiologic links between inflammatory
bowel disease (IBD) and Parkinson disease (PD), clinical data supporting this association …

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

R Macdonald, K Barnes, C Hastings… - Biochemical Society …, 2018 - portlandpress.com
Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines

IC Li, LY Lee, TT Tzeng, WP Chen… - Behavioural …, 2018 - Wiley Online Library
Hericium erinaceus, an ideal culinary‐medicinal mushroom, has become a well‐established
candidate in promoting positive brain and nerve health‐related activities by inducing the …

Sex differences in Parkinson's disease: features on clinical symptoms, treatment outcome, sexual hormones and genetics

JC Jurado-Coronel, R Cabezas, MFÁ Rodríguez… - Frontiers in …, 2018 - Elsevier
Parkinson's disease (PD) is the second most frequent age-related neurodegenerative
disorder. Sex is an important factor in the development of PD, as reflected by the fact that it is …

Mitochondrial calcium imbalance in Parkinson's disease

MHR Ludtmann, AY Abramov - Neuroscience letters, 2018 - Elsevier
Multiple factors are involved in the mechanism (s) of neuronal loss in neurodegenerative
disorders whilst mitochondria are thought to play a central role in neurodegeneration of …

Current perspective of mitochondrial biology in Parkinson's disease

NA Kaidery, B Thomas - Neurochemistry international, 2018 - Elsevier
Parkinson's disease (PD) is one of the most common neurodegenerative movement disorder
characterized by preferential loss of dopaminergic neurons of the substantia nigra pars …

[HTML][HTML] Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine …

A Fujita, H Yamaguchi, R Yamasaki, Y Cui… - Journal of …, 2018 - Springer
Background The first pathology observed in Parkinson's disease (PD) is 'dying back'of
striatal dopaminergic (DA) terminals. Connexin (Cx) 30, an astrocytic gap junction protein, is …

Parkinson's disease: experimental models and reality

P Jiang, DW Dickson - Acta neuropathologica, 2018 - Springer
Parkinson's disease (PD) is a chronic, progressive movement disorder of adults and the
second most common neurodegenerative disease after Alzheimer's disease …