Bicyclo [1.1. 1] pentanes (BCPs) are important bioisosteres of 1, 4-disubstituted arenes, tert-
butyl and acetylenic groups that can impart physicochemical benefits on drug candidates …

The hydrogen-bonding activation for 66 organocatalysts has been quantified using a 31P
NMR binding experiment with triethylphosphine oxide (TEPO). Diverse structural classes …

Sulfanyl‐oxetanes are presented as promising novel bioisosteric replacements for thioesters
or benzyl sulfides. From oxetan‐3‐ols, a mild and inexpensive Li catalyst enables …

GSK3532795, formerly known as BMS-955176 (1), is a potent, orally active, second-
generation HIV-1 maturation inhibitor (MI) that advanced through phase IIb clinical trials. The …

The design and synthesis of a series of C28 amine-based betulinic acid derivatives as HIV-1
maturation inhibitors is described. This series represents a continuation of efforts following …

Studies on the mechanism and intermediate products in the Friedel–Crafts reaction between
oxetanols and phenols are presented. The formation of O-alkylated intermediates is …

The review covers work published in the calendar year 2017. The synthesis and reactivity of
four-membered heteroatom-containing cycles are reviewed. New developments in the …

布洛芬是临床上广泛应用的一种非甾体抗炎药, 有超过50 年的使用历史. 近年来基于布洛芬的
结构修饰仍在进行, 以求获得活性更高的化合物或解决其存在的不良反应. 本文从对布洛芬进行 …

Die Zusammenhänge zwischen der Aktivität Epigenetik-assoziierter Enzyme und
Krankheitsgeschehen neoplastischer Art konnten nicht nur experimentell bestätigt, sondern …

This thesis describes the synthesis, structural preferences and biological properties of
oxetane-containing peptidomimetics in which one of the amide C= O bonds of a peptide …