T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …

Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we
show circulating CD8+ T-cell profiles from patients hospitalized with avian H7N9, seasonal …

Background Prediction of T cell immunogenicity is a topic of considerable interest, both in
terms of basic understanding of the mechanisms of T cells responses and in terms of …

T cell receptor cross-reactivity allows a fixed T cell repertoire to respond to a much larger
universe of potential antigens. Recent work has emphasized the importance of peptide …

CD8+ T cells recognizing antigenic peptides derived from conserved internal viral proteins
confer broad protection against distinct influenza viruses. As memory CD8+ T cells change …

Influenza epidemics lead to severe illness, life-threatening complications, and deaths,
especially in the elderly. As CD8+ T cells are associated with rapid recovery from influenza …

Human leukocyte antigen (HLA)-I molecules generally bind short peptides (8–10 amino
acids), although extended HLA-I restricted peptides (> 10 amino acids) can be presented to …

Despite the widespread use of seasonal influenza vaccines, there is urgent need for a
universal influenza vaccine to provide broad, long-term protection. A number of factors …

T cell function can be compromised during chronic infections or through continuous
exposure to tumor antigens by the action of immune checkpoint receptors, such as …

EBV infection is associated with a number of malignancies of clinical unmet need, including
Hodgkin lymphoma, nasopharyngeal carcinoma, gastric cancer, and posttransplant …