Pharmacogenomic biomarkers for improved drug therapy—recent progress and future developments

VM Lauschke, L Milani, M Ingelman-Sundberg - The AAPS journal, 2018 - Springer
Much of the inter-individual variability in drug efficacy and risk of adverse reactions is due to
polymorphisms in genes encoding proteins involved in drug pharmacokinetics and …

P450 Pharmacogenetics in Indigenous North American Populations

LM Henderson, KG Claw, EL Woodahl… - Journal of personalized …, 2018 - mdpi.com
Indigenous North American populations, including American Indian and Alaska Native
peoples in the United States, the First Nations, Métis and Inuit peoples in Canada and …

Update of the scientific opinion on opium alkaloids in poppy seeds

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2018 - Wiley Online Library
Poppy seeds are obtained from the opium poppy (Papaver somniferum L.). They are used
as food and to produce edible oil. The opium poppy plant contains narcotic alkaloids such …

Diagnosis and perioperative management in pediatric sleep‐disordered breathing

NJ Scalzitti, KM Sarber - Pediatric Anesthesia, 2018 - Wiley Online Library
Sleep‐disordered breathing has a prevalence of 12% in the pediatric population. It
represents a spectrum of disorders encompassing abnormalities of the upper airway that …

Clinical application of pharmacogenetics in pain management

DM Smith, KW Weitzel, LH Cavallari… - Personalized …, 2018 - Future Medicine
There is growing experience translating genomic data into clinical practice, as seen with the
Implementing GeNomics In pracTicE (IGNITE) network. A primary example is the influence of …

Preparing your pediatric patients and their families for the operating room: reducing fear of the unknown

AC Adler, S Leung, BH Lee, SR Dubow - Pediatrics in Review, 2018 - publications.aap.org
The period of time surrounding a planned surgical procedure can be tumultuous and anxiety
provoking for both pediatric patients and their parents. The “mysterious place” that is the …

Pharmacogenomics of analgesics in anesthesia practice: A current update of literature

K Gray, SD Adhikary, P Janicki - Journal of Anaesthesiology …, 2018 - journals.lww.com
The field of pharmacogenomics seeks to understand how an individual's unique gene
sequence can affect their response to certain drugs. It is particularly relevant in anesthesia …

Trends in the management of secondary post-tonsillectomy hemorrhage in children

CM Clark, JR Schubart, MM Carr - International Journal of Pediatric …, 2018 - Elsevier
Objective To define current practices in management of secondary post-tonsillectomy
hemorrhage (PTH) in children by pediatric and general otolaryngologists. Introduction …

Pharmacogenomics, precision medicine, and implications for anesthesia care

AD Kaye, T Mahakian, AJ Kaye, AA Pham… - Best Practice & …, 2018 - Elsevier
The study of how individual genetic differences, known as polymorphisms, change the
pharmacokinetics and pharmacodynamics of drugs is called pharmacogenomics. As the …

Clinician opioid prescribing practices and patient utilization of prescribed opioids in pediatrics

JS Huang, CL Kuelbs - Journal of opioid management, 2018 - wmpllc.org
Objective: Little is known regarding clinician prescribing of opioid medications and of patient
use of prescribed opioid medications in pediatrics. The authors sought to learn more about …