Summary Each year, the American Heart Association (AHA), in conjunction with the Centers
for Disease Control and Prevention, the National Institutes of Health, and other government …

Approximately 20% to 40% of patients with type 1 or type 2 diabetes mellitus develop
diabetic kidney disease. This is a clinical syndrome characterized by persistent albuminuria …

Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste
products, affects 700 million people globally. Genome-wide association studies (GWASs) …

Damage to and loss of glomerular podocytes has been identified as the culprit lesion in
progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with …

Genomic sequencing has undergone massive expansion in the past 10 yr, from a rarely
used research tool into an approach that has broad applications in a clinical setting. From …

Background: Diabetes mellitus (DM) poses a severe threat to global public health. Diabetic
nephropathy (DN) is one of the most common complications of diabetes and the leading …

Most phenome-wide association studies (PheWASs) to date have used a small to moderate
number of SNPs for association with phenotypic data. We performed a large-scale single …

Hereditary distal renal tubular acidosis (dRTA) is a rare genetic disease that is caused by
mutations in SLC4A1, ATP6V1B1, or ATP6V0A4. However, there are many families with …

Drug–drug interactions are a major concern not only during clinical practice, but also in drug
development. Due to limitations of in vitro–in vivo predictions of transporter-mediated drug …

Genome-wide association studies (GWAS) have identified> 100 loci of chronic kidney
disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations …