Numerous biomarkers have been unveiled in the rapidly evolving biomarker discovery field,
with an aim to improve the clinical management of disorders. In rare diseases, such as …

Background and objective Dysferlinopathies are a group of muscle disorders caused by
mutations in the DYSF gene. Previous muscle imaging studies describe a selective pattern …

Objective To provide evidence for quantitative magnetic resonance (qMR) biomarkers in
Duchenne muscular dystrophy by investigating the relationship between qMR measures of …

Introduction: Tests of ambulatory function are common clinical trial endpoints in Duchenne
muscular dystrophy (DMD). Using these tests, the ImagingDMD study has generated a large …

In recent years, quantitative nuclear magnetic resonance imaging and spectroscopy (NMRI
and NMRS) have been used more systematically as outcome measures in natural history …

In vivo musculoskeletal MR imaging plays a critical role in the modern medical practice. The
excellent soft tissue contrast and multiplanar and multiparametric capabilities of MR imaging …

Duchenne muscular dystrophy is the most common and severe form of progressive
muscular dystrophy. Previous results showed an increased survival in double knockout mice …

Introduction: Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary disorder that
causes progressive muscle wasting. This study evaluates the use of proton magnetic …

Quantitative MR is increasingly used to assess muscle damage in muscular dystrophies,
including BMD. Early markers that reflect changes in muscle tissue are becoming …

D uchenne muscular dystrophy (DMD) is the most common X-linked recessive muscular
dysa trophy [1], having an incidence of 1 in 3500 male births. The onset of disease ranges …