Aberrant, misfolded, and mislocalized proteins are often toxic to cells and result in many
human diseases. All proteins and their mRNA templates are subject to quality control. There …

Over 10% of genetic diseases are caused by mutations that introduce a premature
termination codon in protein-coding mRNA. Nonsense-mediated mRNA decay (NMD) is an …

Recursive splicing (RS) starts by defining an" RS-exon," which is then spliced to the
preceding exon, thus creating a recursive 5′ splice site (RS-5ss). Previous studies focused …

The exon junction complex (EJC) deposited upstream of mRNA exon junctions shapes
structure, composition, and fate of spliced mRNA ribonucleoprotein particles (mRNPs). To …

The splicing factor SRSF1 promotes nonsense-mediated mRNA decay (NMD), a quality
control mechanism that degrades mRNAs with premature termination codons (PTCs). Here …

Productive splicing of human precursor messenger RNAs (pre-mRNAs) requires the correct
selection of authentic splice sites (SS) from the large pool of potential SS. Although SS …

The nonsense-mediated mRNA decay (NMD) pathway detects aberrant transcripts
containing premature termination codons (PTCs) and regulates expression of 5–10% of non …

The degree of conservation and evolution of cytoplasmic mRNA metabolism pathways
across the eukaryotes remains incompletely resolved. In this study, we describe a …

During splicing, the exon junction complex (EJC) is deposited upstream of exon-exon
boundaries. The EJC and its peripheral bound proteins play an essential role in mediating …

The exon junction complex (EJC) consists of four core proteins: Magoh, RNA-binding motif
8A (Rbm8a, also known as Y14), eukaryotic initiation factor 4A3 (eIF4A3, also known as …