ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay
M Kamelgarn, J Chen, L Kuang, H Jin… - Proceedings of the …, 2018 - National Acad Sciences
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease
characterized by preferential motor neuron death. Approximately 15% of ALS cases are …
characterized by preferential motor neuron death. Approximately 15% of ALS cases are …
The exon junction complex undergoes a compositional switch that alters mRNP structure and nonsense-mediated mRNA decay activity
The exon junction complex (EJC) deposited upstream of mRNA exon junctions shapes
structure, composition, and fate of spliced mRNA ribonucleoprotein particles (mRNPs). To …
structure, composition, and fate of spliced mRNA ribonucleoprotein particles (mRNPs). To …
NMD-degradome sequencing reveals ribosome-bound intermediates with 3′-end non-templated nucleotides
T Kurosaki, K Miyoshi, JR Myers… - Nature structural & …, 2018 - nature.com
Nonsense-mediated messenger RNA decay (NMD) controls mRNA quality and degrades
physiologic mRNAs to fine-tune gene expression in changing developmental or …
physiologic mRNAs to fine-tune gene expression in changing developmental or …
Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells
P Nicholson, A Gkratsou, C Josi, M Colombo… - Rna, 2018 - rnajournal.cshlp.org
The term “nonsense-mediated mRNA decay”(NMD) originally described the degradation of
mRNAs with premature translation–termination codons (PTCs), but its meaning has recently …
mRNAs with premature translation–termination codons (PTCs), but its meaning has recently …
Interaction entre l'oncoprotéine E6 d'HPV16 et le métabolisme des ARN messagers
K Meznad - 2018 - theses.hal.science
Les papillomavirus humains (HPV) sont des virus à ADN double brin qui infectent la peau et
les muqueuses. Les infections par les HPV, bien que majoritairement asymptomatique …
les muqueuses. Les infections par les HPV, bien que majoritairement asymptomatique …