The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type
p53 can suppress tumour development by multiple pathways. However, mutation of TP53 …

The p53 gene contains homozygous mutations in~ 50–60% of human cancers. About 90%
of these mutations encode missense mutant proteins that span~ 190 different codons …

p53 missense mutant alleles are present in nearly 40% of all human tumors. Such mutated
alleles generate aberrant proteins that not only lose their tumor-suppressive functions but …

The tumor suppressor p53 (TP53) is the most frequently mutated human gene. Mutations in
TP53 not only disrupt its tumor suppressor function, but also endow oncogenic gain-of …

Various evidence has revealed that mutations in p53 exert activities that go beyond simply
inactivation of wildtype functions but rather elicits downstream interactions that promote …

We use a double nanohole optical tweezer to analyze the protein composition of egg white
through analysis of many individual protein trapping events. The proteins are grouped by …

Purpose: Zinc metallochaperones (ZMC) are a new class of anticancer drugs that reactivate
zinc-deficient mutant p53 by raising and buffering intracellular zinc levels sufficiently to …

Restoration of wild-type structure and function to mutant p53 with a small molecule
(hereafter referred to as “reactivating” mutant p53) is one of the holy grails in cancer …

The p53 protein plays a major role in cancer prevention, and over 50% of cancer diagnoses
can be attributed to p53 malfunction. The common p53 mutation Y220C causes local protein …

The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is
regarded as a molecular hub regulating different cell responses, namely cell death …