Mn porphyrin-based redox-active drugs: differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury

I Batinic-Haberle, A Tovmasyan… - Antioxidants & redox …, 2018 - liebertpub.com
Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole …

JM Cline, G Dugan, JD Bourland, DL Perry, JD Stitzel… - Antioxidants, 2018 - mdpi.com
Radiation injury to the lung is the result of acute and chronic free radical formation, and there
are currently few effective means of mitigating such injury. Studies in rodents indicate that …