Classical opioid analgesics, including morphine, mediate all of their desired and undesired
effects by specific activation of the μ‐opioid receptor (μ receptor). The use of morphine for …

Nowadays, the delta opioid receptor (DOPr) represents a promising target for the treatment
of chronic pain and emotional disorders. Despite the fact that they produce limited …

We previously reported that destruction of the small ubiquitin-like modifier (SUMO)
modification site in the axonal collapsin response mediator protein 2 (CRMP2) was sufficient …

There has been significant research to develop an ideal synthetic opioid. Opioids with
variable properties possessing efficacy and with reduced side effects have been …

Aims Previous reports from our laboratory have established that morphine-6-O-sulfate (M6S)
is a mixed μ/δ opioid receptor (OR) agonist and a potential improved alternative to morphine …