Huntington's disease (HD) is a hereditary progressive neurodegenerative disorder caused
by a CAG repeat expansion in the gene coding for the protein huntingtin, resulting in a …

Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …

The identification of the mutation causing Huntington's disease (HD) has led to the
generation of a large number of mouse models. These models are used to further enhance …

Transcriptional changes occur presymptomatically and throughout Huntington's disease
(HD), motivating the study of transcriptional regulatory networks (TRN s) in HD. We …

Hereditary Huntington's disease (HD) is characterized by cell dysfunction and death in the
brain, leading to progressive cognitive, psychiatric, and motor impairments. Despite …

Highlights•Diverse mouse models of HD have important phenotypic and molecular
similarities.•Disconnectivity of the cortico-striatal synapse drives the disease …

Transcriptional dysregulation in Huntington's disease (HD) affects the expression of genes
involved in survival and neuronal functions throughout the progression of the pathology. In …

The three factors, p53, the microRNA-34 family and Sirtuin 1 (SIRT1), interact in a positive
feedback loop involved in cell cycle progression, cellular senescence and apoptosis. Each …

Discriminating transcriptional changes that drive disease pathogenesis from nonpathogenic
and compensatory responses is a daunting challenge. This is particularly true for …

The neurobiological functions of a number of kinases expressed in the brain are unknown.
Here, we report new findings on DCLK3 (doublecortin like kinase 3), which is preferentially …