Chronic or persistent fatigue is a common, debilitating symptom of several diseases.
Persistent fatigue has been associated with low-grade inflammation in several models of …

A wealth of evidence has implicated inflammation in the development of depression. Yet, the
heterogeneous nature of depression has impeded efforts to understand, prevent, and treat …

Highlights•Discrete processes underlying anhedonia can be computationally
operationalized.•Approaches include models of reinforcement learning and effort-based …

Detection and avoidance of sick individuals have been proposed as essential components
in a behavioural defence against disease, limiting the risk of contamination. However …

Effort-based decision making is studied using tasks that offer choices between high-effort
options leading to more highly valued reinforcers versus low-effort/low-reward options …

Human models demonstrate that experimental activation of the innate immune system has
profound effects on brain activation and behavior, inducing fatigue, worsened mood and …

Although at first glance inflammation and social behavior may appear unrelated, research
points to an important role for inflammation in shaping social processes. This review …

Sickness behavior in humans is characterized by low mood and fatigue, which have been
suggested to reflect changes in motivation involving reorganization of priorities. However, it …

The etiology of mood disorders is mechanistically heterogeneous, underscoring the need for
a dimensional approach to identify and develop targeted treatments in psychiatry …

Background People react very differently when sick, and there are only poor correlations
between the intensity of the immune response and sickness behavior. Yet, alternative …