This review provides general information to serve as a primer for those embarking on
understanding food allergy and also details advances and updates in epidemiology …

Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

The atopic march refers to the natural history of allergic diseases as they develop during
infancy and childhood. Introduced by the American allergists AF Coca and RA Cooke in …

Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …

Although oral tolerance is the normal physiologic response to ingested antigens, a
breakdown in this process appears to have occurred in the past 2 decades, leading to an …

The microbiome is vital for immune system development and homeostasis. Changes in
microbial composition and function, termed dysbiosis, in the skin and the gut have recently …

Mast cells (MC s) are innate immune cells that are scattered in tissues throughout the
organism being particularly abundant at sites exposed to the environment such as the skin …

FcεRI is the primary receptor in mast cells that mediates allergic reactions by inducing rapid
release of mediators, an adaptive immune response that might have evolved as a host …

The role of maternal immune responses in tolerance induction is poorly understood. To
study whether maternal allergen sensitization affects offspring susceptibility to food allergy …

Allergic diseases, which include asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS),
atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the …