Incipient and subclinical tuberculosis: a clinical review of early stages and progression of infection
Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …
limited understanding of its clinical pathogenic spectrum of infection and disease …
The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons
Globally, about 36.7 million people were living with HIV infection at the end of 2015. The
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …
Revisiting the timetable of tuberculosis
Revisiting the timetable of tuberculosis Page 1 Revisiting the timetable of tuberculosis OPEN
ACCESS Tuberculosis has a much shorter incubation period than is widely thought, say Marcel …
ACCESS Tuberculosis has a much shorter incubation period than is widely thought, say Marcel …
Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant
Inherited IL-12Rβ1 and TYK2 deficiencies impair both IL-12–and IL-23–dependent IFN-γ
immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 …
immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 …
[HTML][HTML] Progress and challenges in TB vaccine development
G Voss, D Casimiro, O Neyrolles, A Williams… - …, 2018 - ncbi.nlm.nih.gov
Abstract The Bacille Calmette Guerin (BCG) vaccine can provide decades of protection
against tuberculosis (TB) disease, and although imperfect, BCG is proof that vaccine …
against tuberculosis (TB) disease, and although imperfect, BCG is proof that vaccine …
Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis
The transition between latent and active tuberculosis (TB) occurs before symptom onset.
Better understanding of the early events in subclinical disease will facilitate the development …
Better understanding of the early events in subclinical disease will facilitate the development …
The Wonder Years: What Can Primary School Children Teach Us About Immunity to Mycobacterium tuberculosis?
In high burden settings, the risk of infection with Mycobacterium tuberculosis increases
throughout childhood due to cumulative exposure. However, the risk of progressing from …
throughout childhood due to cumulative exposure. However, the risk of progressing from …
Toxin–antitoxin systems and regulatory mechanisms in Mycobacterium tuberculosis
RA Slayden, CC Dawson… - Pathogens and …, 2018 - academic.oup.com
There has been a significant reduction in annual tuberculosis incidence since the World
Health Organization declared tuberculosis a global health threat. However, treatment of M …
Health Organization declared tuberculosis a global health threat. However, treatment of M …
Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae
Background The immune system depends on effector pathways to eliminate invading
pathogens from the host in vivo. Macrophages (MΦ) of the innate immune system are armed …
pathogens from the host in vivo. Macrophages (MΦ) of the innate immune system are armed …
Modelling a silent epidemic: a review of the in vitro models of latent tuberculosis
SER Gibson, J Harrison, JAG Cox - Pathogens, 2018 - mdpi.com
Tuberculosis (TB) is the primary cause of death by a single infectious agent; responsible for
around two million deaths in 2016. A major virulence factor of TB is the ability to enter a …
around two million deaths in 2016. A major virulence factor of TB is the ability to enter a …