Defects in the architecture or integrity of the nuclear envelope are associated with a variety
of human diseases. Micronuclei, one common nuclear aberration, are an origin for …

The nuclear envelope has to be reformed after mitosis to create viable daughter cells with
closed nuclei. How membrane sealing of DNA and assembly of nuclear pore complexes …

High‐content imaging using automated microscopy and computer vision allows multivariate
profiling of single‐cell phenotypes. Here, we present methods for the application of the …

Steroid-resistant nephrotic syndrome (SRNS) almost invariably progresses to end-stage
renal disease. Although more than 50 monogenic causes of SRNS have been described, a …

Objective Galloway–Mowat syndrome (GAMOS) is a neural and renal disorder,
characterized by microcephaly, brain anomalies, and early onset nephrotic syndrome …

The advance of optical super-resolution fluorescence microscopy has revolutionized our
vision of the subcellular world. Further improvement in the spatial resolution is of great …

Nup133 belongs to the Y-complex, a key component of the nuclear pore complex (NPC)
scaffold. Studies on a null mutation in mice previously revealed that Nup133 is essential for …

Genomic imprinting is a phenomenon that restricts transcription to predominantly one
parental allele. How this transcriptional duality is regulated is poorly understood. Here we …

Nuclear pore complexes (NPCs) are gateways through the nuclear envelope. How they form
into a structure containing three rings and integrate into the nuclear envelope remains a …

In metazoa, the Nup107 complex (also known as the nucleoporin Y-complex) plays a major
role in formation of the nuclear pore complex in interphase and is localised to kinetochores …