Despite their importance, our understanding of noncovalent RNA–protein interactions is
incomplete. This especially concerns the binding between RNA and unstructured protein …

RNA-protein (RNP) interactions play essential roles in many biological processes, such as
regulation of co-transcriptional and post-transcriptional gene expression, RNA splicing …

Molecular docking provides a computationally efficient way to predict the atomic structural
details of protein–RNA interactions (PRI), but accurate prediction of the three-dimensional …

Structural information about protein–RNA complexes supports the understanding of crucial
recognition processes in the cell, and it can allow the development of high affinity ligands to …

Weak protein–protein interactions may be important to binding cooperativity. A panel of
seven fluorescently labeled tracer monoclonal IgG antibodies, differing in variable (V) and …

Molecular modeling by means of docking and molecular dynamics (MD) has become an
integral part of early drug discovery projects, enabling the screening and enrichment of large …

RNA–protein interactions occur in many biological processes. To understand the
mechanism of these interactions one needs to know three-dimensional (3D) structures of …

Intrinsically disordered regions (IDRs) and protein (IDPs) are highly flexible owing to their
lack of well-defined structures. A subset of such proteins interacts with various substrates; …

Protein-RNA interactions play an important role in many biological processes.
Computational methods such as docking have been developed to complement existing …

Modulating protein interaction pathways may lead to the cure of many diseases. Known
protein–protein inhibitors bind to large pockets on the protein–protein interface. Such large …