Sulfur metabolism is integral to cellular growth and survival. The presence of a wide range of
oxidation states of sulfur in biology coupled with its unique reactivity are some key features …

Background Angiogenesis is considered as an important process in the development of
malignancies and is associated with cancer progression and metastasis. Hepatocellular …

Oxidative stress and inflammation are important critical factors that are implicated in almost
all life style disorders such as diabetes, cardiovascular disease, ulcer and cancer. Current …

Hypoxia-induced radioresistance is the primary reason for failure of tumor radiotherapy (RT).
Changes within the irradiated tumor microenvironment (TME) including oxygen, reactive …

Angiogenesis has always been considered as a fundamental therapeutic target for inhibiting
tumor growth and metastasis. To date, anti-angiogenic treatments that have been approved …

Background Mesenchymal transformation of pulmonary endothelial cells contributes to the
formation of a metastatic microenvironment, but it is not known whether this precedes or …

Metastasis formation requires active energy production and is regulated at multiple levels by
mitochondrial metabolism. The hyperactive metabolism of cancer cells supports their …

Currently, there is no effective therapy for the treatment of highly metastatic triple-negative
breast cancer (TNBC). Microvesicle (MV) formation is crucial for the metastasis of TNBC …

High levels of both nitric oxide (NO) and reactive oxygen species (ROS) could act as pro-
apoptotic signals in cancerous cells. In this study, we conjugated diazeniumdiolates …

Colorectal carcinogenesis (CRC) is the most important health concerns throughout the
World as the tumour cells rapidly spread and abruptly grow in colon and rectum to further …