Accumulating evidence suggests that epigenetic alterations lie behind the induction and
maintenance of neuropathic pain. Neuropathic pain is usually a chronic condition caused by …

Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and
controlled by a complement of ion channels it expresses, in order to understand and treat …

Summary α2δ-1, commonly known as a voltage-activated Ca 2+ channel subunit, is a
binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is …

Nerve injury-induced hyperactivity of primary sensory neurons in the dorsal root ganglion
(DRG) contributes to chronic pain development, but the underlying epigenetic mechanisms …

Objective Persistent pain causes untold misery worldwide and is a leading cause of
disability. Despite its astonishing prevalence, pain is undertreated, at least in part because …

Abstract The sodium channel 1.7 (Nav1. 7), which is encoded by SCN9A gene, is involved in
neuropathic pain. As crucial regulators of gene expression, many miRNAs have already …

G-protein-coupled receptors are considered to be cell-surface sensors of extracellular
signals, thereby having a crucial role in signal transduction and being the most fruitful …

Neuropathic pain is associated with persistent changes in gene expression in primary
sensory neurons, but the underlying epigenetic mechanisms that cause these changes …

Chronic orofacial pain is a significant health problem requiring identification of regulating
processes. Involvement of epigenetic modifications that is reported for hindlimb neuropathic …

The Neuron Restrictive Silencer Factor (NRSF) is the well-known master transcriptional
repressor of the neuronal phenotype. Research to date has shown that it is an important …