Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Highlights•Isoforms and posttranslational modifications generate the tubulin code for
neuronal polarization.•Tubulin isoforms have distinct properties and functions.•Tubulin …

Growing evidence supports the implication of DYRK1A in the development of cognitive
deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate …

Mutations and copy number variants affecting DYRK1A gene encoding the dual-specificity
tyrosine phosphorylation-regulated kinase 1A are among the most frequent genetic causes …

Proper neuronal wiring is central to all bodily functions, sensory perception, cognition,
memory, and learning. Establishment of a functional neuronal circuit is a highly regulated …

Microtubule self-assembly dynamics serve to facilitate many vital cellular functions, such as
chromosome segregation during mitosis and synaptic plasticity. However, the detailed …

We present the development of conformationally pre-organised Dyrk1A inhibitors based on
the hydroxybenzothiazole urea scaffold. The modifications introduced to the discovered hit …

The Down syndrome and microcephaly related gene Mnb/Dyrk1A encodes an evolutionary
conserved protein kinase subfamily that plays important roles in neurodevelopment …

New motifs for phosphorylation sites associated with calcium-dependent protein kinases
were developed using 494 sites experimentally proved in mammalians. Subsequent motif …

ABSTRACT ANK2 is a high-confidence autism spectrum disorder (ASD) gene where
affected individuals exhibit diverse symptoms with a wide range of IQ. We report a cellular …