The independence of and associations among apoptosis, autophagy, and necrosis
Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
Opportunities for the repurposing of PARP inhibitors for the therapy of non‐oncological diseases
NA Berger, VC Besson, AH Boulares… - British journal of …, 2018 - Wiley Online Library
The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for
potential therapeutic repurposing for non‐oncological indications. Considering (a) the …
potential therapeutic repurposing for non‐oncological indications. Considering (a) the …
High speed of fork progression induces DNA replication stress and genomic instability
A Maya-Mendoza, P Moudry, JM Merchut-Maya… - Nature, 2018 - nature.com
Accurate replication of DNA requires stringent regulation to ensure genome integrity. In
human cells, thousands of origins of replication are coordinately activated during S phase …
human cells, thousands of origins of replication are coordinately activated during S phase …
The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third …
Background and Purpose The PARP inhibitor olaparib has recently been approved for
human use for the therapy of cancer. Considering the role of PARP in critical illness, we …
human use for the therapy of cancer. Considering the role of PARP in critical illness, we …
Biochemical and genetic analysis of a unique poly(ADP-ribosyl) glycohydrolase (PARG) of the pathogenic fungus Fusarium oxysporum f. sp. lycopersici
CA Araiza-Cervantes, V Meza-Carmen… - Antonie van …, 2018 - Springer
The genome sequence of the plant pathogen Fusarium oxysporum f. sp. lycopersici contains
a single gene encoding a predicted poly (ADP-ribose) glycohydrolase (FOXG_05947. 2 …
a single gene encoding a predicted poly (ADP-ribose) glycohydrolase (FOXG_05947. 2 …