Genome-wide association studies (GWAS) were successful to identify genetic factors
robustly associated with lung cancer. This review aims to synthesize the literature in this field …

Cancer is a complex genetic disease that develops from the accumulation of genomic
alterations in which germline variations predispose individuals to cancer and somatic …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Cervical cancer (CC) is the third most common malignancy in women globally, and
persistent infection with the oncogenic human papillomaviruses (HPV) is recognized as the …

Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage
response at chromosome ends, which leads to the induction of senescence and/or …

Telomere length (TL) is an index of cellular aging and can predict the incidences of many
age-related diseases. Change of TL might be affected by environmental pollution and …

Expression of the eukaryotic genome is a highly complex and tightly regulated process, and
its regulation depends on interactions among cis-acting elements and transcription factors …

Background: There exists compelling evidence that some genetic variants are associated
with the risk of multiple cancer sites (ie, pleiotropy). However, the biological mechanisms …

Single nucleotide polymorphisms (SNP s) may modulate individual susceptibility to
carcinogens. We designed a genome‐wide association study to characterize individuals …

Background: Cancer remains a leading cause of death and constitutes an enormous burden
on society worldwide. The association between the human telomerase reverse transcriptase …