Epigenetics applied to psychiatry: clinical opportunities and future challenges
L Kular, S Kular - Psychiatry and clinical neurosciences, 2018 - Wiley Online Library
Psychiatric disorders are clinically heterogeneous and debilitating chronic diseases
resulting from a complex interplay between gene variants and environmental factors …
resulting from a complex interplay between gene variants and environmental factors …
[HTML][HTML] Environmental enrichment improves cognitive deficits, AD hallmarks and epigenetic alterations presented in 5xFAD mouse model
C Griñán-Ferré, V Izquierdo, E Otero… - Frontiers in Cellular …, 2018 - frontiersin.org
Cumulative evidence shows that modifications in lifestyle factors constitute an effective
strategy to modulate molecular events related to neurodegenerative diseases, confirming …
strategy to modulate molecular events related to neurodegenerative diseases, confirming …
[HTML][HTML] Exercising new neurons to vanquish Alzheimer disease
M Llorens-Martín - Brain plasticity, 2018 - content.iospress.com
Alzheimer disease (AD) is the most common type of dementia in individuals over 65 years of
age. The neuropathological hallmarks of the condition are Tau neurofibrillary tangles and …
age. The neuropathological hallmarks of the condition are Tau neurofibrillary tangles and …
Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study
Aim: The present study investigated the link between peripheral DNA methylation (DNAm),
cognitive impairment and brain aging. Methods: We tested the association between blood …
cognitive impairment and brain aging. Methods: We tested the association between blood …
[HTML][HTML] Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice
P Jessop, M Toledo-Rodriguez - Frontiers in cell and developmental …, 2018 - frontiersin.org
The function of 5-hydroxymethylcytosine (5hmC) is poorly understood. 5hmC is an
epigenetic modification of DNA, resulting from the oxidation of 5-methylcytosine (5mC) by …
epigenetic modification of DNA, resulting from the oxidation of 5-methylcytosine (5mC) by …
Defective DNA Methylation/Demethylation Processes Define Aging-Dependent Methylation Patterns
M Zampieri, F Ciccarone, P Caiafa - Epigenetics of Aging and Longevity, 2018 - Elsevier
The process of aging culminates in a multitude of chronological irreversible changes at the
cellular and molecular levels that push the organism toward a progressive loss of …
cellular and molecular levels that push the organism toward a progressive loss of …