To optimally penetrate biological hydrogels such as mucus and the tumor interstitial matrix,
nanoparticles (NPs) require physicochemical properties that would typically preclude …

Since the late sixties, platelet concentrates are transfused to patients presenting with severe
thrombocytopenia, platelet function defects, injuries, or undergoing surgery, to prevent the …

Traumatic non-compressible hemorrhage is a leading cause of civilian and military mortality
and its treatment requires massive transfusion of blood components, especially platelets …

Human platelets play important roles in several physiologic and pathologic processes. Any
defects in platelet number and function can lead to a variety of bleeding complications; …

BACKGROUND Clinical resuscitative treatment of traumatic hemorrhage involves
transfusion of RBC, platelets and plasma in controlled ratios. However, use of such blood …

Inspired by the nature, the biomimetic nanomaterial design strategies have attracted great
interest because the bioinspired nanoplatforms may enhance the functionality of current …

Essentials• Platelet transfusions can have limited efficacy during hemorrhage associated
with coagulopathy.• Thrombin can be shielded by encapsulation into nanoliposomes and …

Excessive bleeding and resulting complications are a major cause of death in both trauma
and surgical settings. Recently, there have been a number of investigations into the design …

Thrombosis or embolism is the leading cause of death and long-term adult disability
worldwide. To reduce the risk of thrombosis and hemorrhaging in patients, a facile and …

Platelets are small, anucleate blood cells that are important mediators of many physiological
and pathological processes. These include hemostasis, thrombosis, wound healing …